Dietary Intake of Nutrients Involved in One-Carbon Metabolism and Risk of Gastric Cancer: A Prospective Study

PA Dugué; JK Bassett; MT Brinkman; MC Southey; JE Joo; EM Wong; RL Milne; DR English; GG Giles; A Boussioutas; H Mitchell; AM Hodge

Journal article

Dietary Intake of Nutrients Involved in One-Carbon Metabolism and Risk of Gastric Cancer: A Prospective Study

PA Dugué, JK Bassett, MT Brinkman, MC Southey, JE Joo, EM Wong, RL Milne, DR English, GG Giles, A Boussioutas, H Mitchell, AM Hodge

Nutrition and Cancer | ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD | Published : 2019

DOI: 10.1080/01635581.2019.1577982

Abstract

Dietary intakes of B vitamins and other components involved in one-carbon metabolism, which is necessary for DNA replication, DNA repair, and regulation of gene expression, may be associated with carcinogenesis. We investigated associations between intakes of 11 nutrients (thiamine, riboflavin, niacin, pantothenic acid, vitamin B6, biotin, folate, vitamin B12, methionine, choline, and betaine) and gastric cancer risk. A total of 159 incident gastric cancer cases were identified from the Melbourne Collaborative Cohort Study (N = 41,513) and matched with 159 controls on year of birth, sex, and country of birth using incidence density sampling. Dietary intakes of nutrients were estimated at bas..

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University of Melbourne Researchers

Pierre-Antoine Dugue Author

Melissa Southey Author

Eric Joo Author

Roger Milne Author

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Grants

Awarded by VicHealth

Funding Acknowledgements

The Melbourne Collaborative Cohort Study (MCCS) was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian National Health and Medical Research Council [grant numbers: 209057, 251553, 1087683, 396414 and 1074383] and by infrastructure provided by Cancer Council Victoria.